Synthesis of Novel Spiro Pyrrolidine and Pyrrolizine Derivatives by 1,3-Dipolar Cycloaddition |
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| Authors: | Li Xiaofang Zheng Aiting Liu Bin Yu Xianyong Yi Pinggui |
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| Institution: | 1. Key Laboratory of Theoretical Chemistry and Molecular Simulation of Ministry of Education, Hunan Province College Key Laboratory of QSAR/QSPR, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, Hunan 411201, China;2. School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China |
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| Abstract: | The 1,3‐dipolar cycloaddition of azomethine ylides derived from isatin and amino acids viz. sarcosine and proline to 2‐arylmethylidene‐5,6‐dihydroimidazo2,1‐b]thiazol‐3(2H)‐ones afforded novel spiro pyrrolidines and pyrrolizidines regio‐ and stereoselectively in moderate yields. The products were characterized thoroughly by IR, MS, NMR together with elementary analysis. |
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| Keywords: | spiroheterocycle 1 3‐dipolar cycloaddition azomethine ylides dihydroimidazo[2 1‐b]thiazol‐3(2H)‐one |
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