Lariatins, antimycobacterial peptides produced by Rhodococcus sp. K01-B0171, have a lasso structure |
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Authors: | Iwatsuki Masato Tomoda Hiroshi Uchida Ryuji Gouda Hiroaki Hirono Shuichi Omura Satoshi |
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Affiliation: | Kitasato Institute, Kitasato University, Minato-ku, Tokyo 108, Japan. |
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Abstract: | Two antimycobacterial agents, lariatins A and B, were isolated from the culture broth of Rhodococcus sp. K01-B0171. Their structures were elucidated by spectral analysis and advanced protein chemical methods to be unique cyclic peptides, which consist of 18 and 20 L-amino acid residues with an internal linkage between the gamma-carboxyl group of Glu8 and the alpha-amino group of Gly1. The three-dimensional structure of lariatin A deduced from NMR data by dynamical simulated annealing method indicates that the tail segment (Trp9-Pro18) passes through the ring segment (Gly1-Glu8) to form a 'lasso' structure. |
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