Direct synthesis of novel amphiphilic cyclodextrin

A novel amphiphilic cyclodextrin derivative was obtained by controlled esterification of lauric acid chloride on the primary face of the native β-cyclodextrin in a one step synthesis. The characterization of the substitution degree and isomer structure was performed by mass and NMR spectroscopies. A specific purification procedure by sublimation was developed in order to eliminate the excess of lauric acid molecules in the reaction product. The sublimation efficiency was assessed by differential scanning calorimetry (DSC) in quantifying the remaining fatty acid. In this way the duration of the sublimation process could be optimized.