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Synthesis, spectral properties, crystal structures and antimicrobial effects of copper(II) pyridinecarboxylate adducts with chelating ligands |
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| Institution: | a Department of Inorganic Chemistry, Slovak Technical University, 812 37 Bratislava, Slovak Republic b Department of Biochemistry and Microbiology, Slovak Technical University, 812 37 Bratislava, Slovak Republic c Institute of Chemistry, University of Wroclaw, F. Joliot-Curie 14, 50 383 Wroclaw, Poland |
| Abstract: | The reaction of an ethanolic solution of copper(II) pyridinecarboxylates CuX2·nH2O (where X is nicotinate (nic) (n=0) or isonicotinate (isonic) (n=4)) with ethylenediamine (en) in a molar ratio of 1:2 lead to the isolation of solid tetragonally distorted octahedral complexes of the type Cu(en)2(H2O)2]X2·nH2O (n=1 for nic; n=0 for isonic). The analogous reaction of CuX2·nH2O with diethylenetriamine (dien) in a molar ratio of 1:1 leads to the formation of square-pyramidal pentacoordinated complexes of the type CuX(dien)(H2O)]X. On the other hand, the reaction of equimolar quantities of copper(II) nitrate and dien with nicotinate anions (equimolar quantities of pyridinecarboxylic acid and NaOH) in ethanolic solutions gives a solid monomeric complex Cu(nic)(NO3)dien)(H2O)]·H2O in which the coordination polyhedron around the Cu(II) atom is a (4+1+1) distorted tetragonal bipyramid. Based on the molecular structure the electronic and IR spectra are discussed. Moreover, the results of the quantitative determination of antimicrobial activity of the isonic complexes Cu(isonic)2(H2O)4], Cu(en)2(H2O)2](isonic)2, Cu(isonic)(dien)(H2O)](isonic), as well as isonicotinic acid, ethylenediamine and diethylenetriamine alone are discussed. |
| Keywords: | Chelating ligands Crystal structures Copper(II) complexes Pyridinecarboxylate complexes Antimicrobial activity |
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