Efficient Synthesis of New Tetracyclic Benzofuro[3,2-d]-imidazo[1,2-a] pyrimidine-2,5-(1 H,3 H)-diones |
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| Authors: | Hu Yanggen Liu Min Ding Mingwu |
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| Affiliation: | 1. Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, Central China Normal University, Wuhan, Hubei 430079, China;2. Department of Pharmacy, Taihe Hospital of Yunyang Medical College and Institute of Medicine Chemistry, Yunyang Medical College, Shiyan, Hubei 442000, China;3. Tel.: 0086‐027‐63158845;4. Fax: 0086‐027‐67862041 |
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| Abstract: | The aza‐Wittig reaction of iminophosphorane ( 1 ) with aromaic isocyanates gave carbodiimides ( 2 ), which were allowed to react further with (‐amino ester in the presence of a catalytic amount of sodium ethoxide to give selectively new tetracyclic benzofuro[3,2‐d]imidazo[1,2‐a]pyrimidine‐2,5‐(1H,3H)‐diones ( 5 ) in good yields. X‐ray structure analysis of 5i verified the proposed structure and the reaction selectivity. |
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| Keywords: | benzofuro[3,2‐d]imidazo[1,2‐a]pyrimidine‐2,5‐(1H,3H)‐dione iminophosphorane aza‐Wittig reaction isocyanate carbodiimide |
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