A sonochemical route for the encapsulation of drug in magnetic microspheres |
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| Authors: | Shixi WuWei Jiang Xiaojuan ZhangHuan Sun Wenyao ZhangJunjun Dai Li LiuXiaolong Chen Fengsheng Li |
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| Affiliation: | a National Special Superfine Powder Engineering Research Center, Nanjing University of Science and Technology, Nanjing 210094, China
b School of Material Engineering, Jinling Institute of Technology, Nanjing 211169, China |
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| Abstract: | This study focused on the preparation and characterization of magnetic targeted antibiotic microspheres (MTAMs). MTAMs were prepared by a sonochemical method in the presence of hydrophobic Fe3O4 nanoparticles and tetracycline. The properties of MTAMs were characterized by transmission electron microscopy, Fourier-transform infrared spectrum, thermogravimetric analysis, vibration sample magnetometry, and bacteriostatic experiment. The results indicated that the superparamagnetic microspheres have ultrafine size (below 230 nm), high saturation magnetization (80.90 emu/g), high biocompatibility, biodegradability, controlled-release, and antibiotic effect. It has been proved that MTAMs can carry out the function of magnetic targeted drugs delivery system by putting together magnetic materials and antibiotics. The possible formation mechanism of MTAMs was also discussed. In summary, MTAMs had potential in medical imaging, drug targeting, and catalysis. |
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| Keywords: | Nanocomposite Nanoparticle Biomaterial Magnetic material Antibiotic effect |
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