Biosynthesis of cervimycin C, an aromatic polyketide antibiotic bearing an unusual dimethylmalonyl moiety |
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Authors: | Herold Kerstin Xu Zhongli Gollmick Friedrich A Grafe Udo Hertweck Christian |
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Affiliation: | Department of Biostructure Chemistry, Hans-Knoll-Institute for Natural Products Research, Beutenbergstr. 11a, 07745, Jena, Germany. |
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Abstract: | Cervimycin C is the major component of an antibiotic complex produced by Streptomyces tendae HKI-179 consisting of a tetracycline-type aglycon, six tridesoxysugars and a rare dimethylmalonyl moiety. The biosynthetic origin of cervimycin was studied by molecular studies and feeding experiments, which reveal that the dimethylmalonate unit is not derived from malonate, but from valine. |
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