Evolutionary dynamics of RNA-like replicator systems: A bioinformatic approach to the origin of life |
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Authors: | Nobuto Takeuchi Paulien Hogeweg |
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Institution: | 1. National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 8600 Rockville Pike, Bethesda, MD 20894, USA;2. Theoretical Biology and Bioinformatics Group, Utrecht University, Padualaan 8, 3584CH Utrecht, The Netherlands |
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Abstract: | We review computational studies on prebiotic evolution, focusing on informatic processes in RNA-like replicator systems. In particular, we consider the following processes: the maintenance of information by replicators with and without interactions, the acquisition of information by replicators having a complex genotype–phenotype map, the generation of information by replicators having a complex genotype–phenotype–interaction map, and the storage of information by replicators serving as dedicated templates. Focusing on these informatic aspects, we review studies on quasi-species, error threshold, RNA-folding genotype–phenotype map, hypercycle, multilevel selection (including spatial self-organization, classical group selection, and compartmentalization), and the origin of DNA-like replicators. In conclusion, we pose a future question for theoretical studies on the origin of life. |
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