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Synthesis and Biological Activity of Cyanoethyl Derivatives of Fusidic Acid |
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| Authors: | Salimova E. V. Mamaev A. G. Tret’yakova E. V. Kukovinets O. S. Mavzyutov A. R. Shvets K. Yu. Parfenova L. V. |
| Affiliation: | 1.Institute of Petrochemistry and Catalysis, Russian Academy of Sciences, tpr. Oktyabrya 141, Ufa, 450075 Bashkortostan, Russia ;2.Bashkir State University, tul. Zaki Validi 32, Ufa, 450076 Bashkortostan, Russia ;3.Bashkir State Medical University, ul. Lenina 3, Ufa, 450008 Bashkortostan, Russia ; |
| Abstract: | 3,11-Dihydroxy and 3,11-dioxo triterpenoids of the fusidane series reacted with acrylonitrile in 1,4-dioxane in the presence of alkali and phase-transfer catalyst to give mono- and bis(2-cyanoethoxy) and 2-cyanoethyl derivatives. The reaction with 3,11-dioxo analog afforded 2,2-disubstituted derivative as a result of addition of two cyanoethyl groups to the α-position with respect to the C3=O carbonyl group. The isolated compounds were screened for antibacterial and antifungal activities. |
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