Asymmetric hydrogenation of ketones using a ruthenium(II) catalyst containing BINOL-derived monodonor phosphorus-donor ligands |
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Authors: | Xu Yingjian Alcock Nat W Clarkson Guy J Docherty Gordon Woodward Gary Wills Martin |
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Affiliation: | Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK. |
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Abstract: | [structure: see text] A series of ruthenium(II) complexes containing BINOL-based monodonor phosphorus ligands have been prepared and applied to the asymmetric catalysis of the hydrogenation of aryl/alkyl ketones. The best ligands for this application are those which contain an aromatic groups with either a methoxide or bromide on the ortho position. Using these ligands, alcohols with ee's of up to 99% are formed. |
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