Iron-catalyzed highly regio- and stereoselective conjugate addition of 2,3-allenoates with Grignard reagents |
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| Authors: | Lu Zhan Chai Guobi Ma Shengming |
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| Institution: | Laboratory of Molecular Recognition and Synthesis, Department of Chemistry, Zhejiang University, Hangzhou 310027, Zhejiang, PR China. |
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| Abstract: | An efficient highly regio- and stereoselective iron-catalyzed conjugate addition of 2,3-allenoates with primary or secondary alkyl, phenyl, or vinyl Grignard reagents to synthesize multi-substituted beta,gamma-unsaturated enoates has been reported. The in situ formed magnesium dienolate may readily react with different electrophilic reagents to construct an allylic quaternary carbon at the alpha-position of the ester group. |
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