A facile one-pot benzylation of sodium enolates using trifluoromethanesulfonic anhydride and diphenyl sulfoxide |
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Authors: | Takuwa Tomofumi Minowa Tomofumi Fujisawa Hidehiko Mukaiyama Teruaki |
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Affiliation: | Center for Basic Research, The Kitasato Institute, 6-15-5 (TCI) Toshima, Tokyo 114-0003, Japan. |
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Abstract: | A facile one-pot C-benzylation of various sodium enolates derived from methyl malonate, beta-ketoesters, a beta-cyanoester, a beta-cyanosulfone, ketones and a carboxylic ester is reported. Reaction of alkoxydiphenylsulfonium salts formed by treating various benzyl alcohols with diphenyl sulfide bis(trifluoromethanesulfonate) (derived from trifluoromethanesulfonic anhydride and diphenyl sulfoxide) proceeded smoothly, and the corresponding C-benzylated products were afforded in good to high yields. |
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