Cationic dirhodium carboxylate-catalyzed synthesis of dihydropyrimidones from propargyl ureas期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Cationic dirhodium carboxylate-catalyzed synthesis of dihydropyrimidones from propargyl ureas

Authors:	Miao Yang Shannon J Odelberg Zongzhong Tong Dean Y Li Ryan E Looper

Institution:	1. Department of Chemistry, University of Utah, Salt Lake City, UT 84112, United States;2. Department of Medicine, Cardiology Division, University of Utah, Salt Lake City, UT 84132, United States;3. Program in Molecular Medicine, University of Utah, Salt Lake City, UT 84112, United States;4. Navigen Inc., Salt Lake City, UT 84108, United States;5. Department of Oncology, University of Utah, Salt Lake City, UT 84112, United States;6. The Key Laboratory for Human Disease Study of Sichuan Province, Institute of Laboratory Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People''s Hospital, Chengdu, Sichuan 610072, China

Abstract:	Cationic Rh(II) complexes are able to catalyze the regioselective hydroamination of propargyl ureas in a 6-endo fashion. This transformation permits access to interesting substitution patterns of dihydropyrimidines, which have found use as nucleotide exchange factor inhibitors.

Keywords:	Dihydropyrimidone Heterocycle Hydroamination Rhodium catalysis ARF 6
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