New azaphilones from Chaetomium globosum isolated from the built environment |
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| Authors: | David R. McMullin Mark W. Sumarah Barbara A. Blackwell J. David Miller |
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| Affiliation: | 1. Ottawa Carleton Institute of Chemistry, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario, Canada K1S 5B6;2. Eastern Cereal and Oilseed Research Centre, Agriculture and Agri-Food Canada, 960 Carling Avenue, Ottawa, Ontario, Canada K1A 0C6 |
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| Abstract: | A strain of Chaetomium globosum (DAOM 240359) was isolated from an indoor air sample in Ottawa, Ontario, Canada. When fermented in liquid culture, this strain produced a number of known metabolites including chaetoglobosins A (6), C, and F (7), chaetomugilin D (5), chaetoviridin A (4), and three new nitrogenous azaphilones; 4′-epi-N-2-hydroxyethyl-azachaetoviridin A (1), N-2-butyric-azochaetoviridin E (2), and isochromophilone XIII (3). The structures were elucidated by spectroscopic analysis including; HRMS, 1D and 2D NMR, UV, and ORD. Compounds 2–7 were antimicrobial when tested using quantitative growth inhibition assays. |
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