Building block synthesis of predominantly (E) symmetrical and unsymmetrical 1,2-difluorostilbenes from 1,2-dibromo-1,2-difluoroethene |
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Authors: | Said Eddarir Mohammed Kajjout Christian Rolando |
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Affiliation: | 1. Université de Lille 1, Sciences et Technologies, Miniaturisation pour la Synthèse, l''Analyse & la Protéomique (MSAP), USR CNRS 3290 and Institut Michel Chevreul FR CNRS 2698, 59655 Villeneuve d''Ascq Cedex, France;2. Université Cadi Ayyad, Faculté des Sciences et Techniques Guéliz, BP 549 Marrakech, Morocco |
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Abstract: | An efficient synthesis of predominantly (E) symmetrical or unsymmetrical 1,2-difluorostilbenes based on the Suzuki–Miyaura palladium-catalyzed cross-coupling reaction of arylboronic acids with predominantly (E)-1,2-dibromo-1,2-difluoroethene in the presence of Cs2CO3 in toluene is described. The reaction preserved the stereochemistry of the building block and performed in good yield independently of the electron-withdrawing or electron-donating character of the substituents. |
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Keywords: | 1,2-Difluorostilbenes Palladium Cross-coupling Catalysis Building block |
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