A novel synthesis of 1-aryl-3-piperidone derivatives |
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| Authors: | Yinan Zhang Richard B. Silverman |
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| Affiliation: | Department of Chemistry, Chemistry of Life Processes Institute, Center for Molecular Innovation and Drug Design, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, USA |
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| Abstract: | A novel method to construct the 1-aryl-3-piperidone scaffold is described here. Starting from 3,5-dichloroaniline, a seven-step synthesis, without the use of protecting groups, generates the desired 3-piperidone ring in an overall yield of 30% through a key Morita–Baylis–Hillman reaction and ring-closing metathesis, providing easy access to diverse and useful heterocycles. |
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