Gd‐TEMDO: Design,Synthesis, and MRI Application
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| Authors: | André Boltjes Dr Annadka Shrinidhi Kees van?de?Kolk Dr Eberhardt Herdtweck Prof?Dr Alexander Dömling |
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| Institution: | 1. Department of Drug Design, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, The Netherlands;2. Central Animal Facility, University of Groningen/UMCG, The Netherlands;3. Institut für Anorganische Chemie, Technische Universit?t München, Garching bei München, Germany |
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| Abstract: | A simple Ugi tetrazole multicomponent reaction allows the synthesis of a novel macrocyclic cyclen derivative with four appendant tetrazole arms in just two steps in excellent yields. This ligand, called TEMDO, turns out to have a high complexation affinity with lanthanoid metals. Here we describe the design, synthesis, solid‐state structure, binding constant, and some MRI applications of the Gd‐TEMDO complex as the first example of a congeneric family of oligo‐amino tetrazoles. |
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| Keywords: | gadolinium macrocyclic ligands magnetic resonance imaging multicomponent reactions oligoamino tetrazole |
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