Synthesis of Novel Imidazo[1,2‐a]pyridin‐2‐amines from Arylamines and Nitriles via Sequential Addition and I2/KI‐Mediated Oxidative Cyclization |
| |
| Authors: | Xianhai Tian Lina Song Manman Wang Zhigang Lv Dr. Jie Wu Dr. Wenquan Yu Prof. Dr. Junbiao Chang |
| |
| Affiliation: | 1. College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, P. R. China;2. Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, Zhengzhou, P. R. China |
| |
| Abstract: | A novel and practical strategy for the construction of imidazo[1,2‐a]pyridin‐2‐amine frameworks has been developed. The present sequential approach involves addition of arylamines to nitriles and I2/KI‐mediated oxidative C?N bond formation without purification of the intermediate amidines. This operationally simple synthetic process provides a facile access to a variety of new 2‐amino substituted imidazo[1,2‐a]pyridines and related heterocyclic compounds in an efficient and scalable fashion. |
| |
| Keywords: | C− N bond formation iodine imidazo[1,2-a]pyridin-2-amine oxidative cyclization sequential synthesis |
|
|
