1,2‐Thiazines: One‐Pot Syntheses Utilizing Mono and Diaza Analogs of Sulfones |
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| Authors: | Rebekka Anna Bohmann Yuto Unoh Prof?Dr Masahiro Miura Prof?Dr Carsten Bolm |
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| Institution: | 1. Institute of Organic Chemistry, RWTH Aachen University, Aachen, Germany), Fax;2. Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Suita, Osaka, Japan;3. +49)?241‐8092391 |
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| Abstract: | A one‐pot Michael addition/cyclization/condensation reaction sequence for the regioselective synthesis of 1,2‐thiazines, starting from propargyl ketones and NH‐sulfoximines or NH‐sulfondiimines, has been developed. Under mild and operationally simple reaction conditions previously unprecedented 1,2‐thiazine 1‐imide and 1‐oxide derivatives are formed in good to excellent yields. The products represent heterocyclic building blocks, readily modifiable by a regioselective C?H bond functionalization, classical cross‐coupling reactions, and deprotection. |
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| Keywords: | cyclization heterocycles Michael addition sulfoximines thiazines |
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