|
|||||
|
|
New Chiral Reagent for Installation of Pharmacophoric (S)‐ or (R)‐2‐(Alkoxyphosphono)‐1‐amino‐2,2‐difluoroethyl Groups |
|
| Authors: | Chen Xie Lijun Zhang Dr Haibo Mei Dr Romana Pajkert Dr Maksym Ponomarenko Dr Yi Pan Prof Dr Gerd‐Volker Röschenthaler Prof Dr Vadim A Soloshonok Dr Jianlin Han |
| Institution: | 1. School of Chemistry and Chemical Engineering, State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing, P. R. China;2. Department of Life Sciences and Chemistry, Jacobs University Bremen gGmbH, Bremen, Germany;3. Department of Organic Chemistry I, Faculty of Chemistry, University of the Basque Country UPV/EHU, San Sebastián, Spain;4. IKERBASQUE, Basque Foundation for Science, Bilbao, Spain |
| Abstract: | A new chiral reagent has been developed for generalized installation of pharmacophoric (S)‐ or (R)‐2‐(alkoxyphosphono)‐1‐amino‐2,2‐difluoroethyl group into organic compounds. The original synthetic application of this new reagent is exemplified by Friedel–Crafts reactions with indoles, which proceed efficiently with excellent diastereoselectivity to give enantiomerically pure products. |
| Keywords: | asymmetric synthesis Friedel– Crafts imine indoles synthetic methods |