Enantiomeric resolution of new triazole compounds by high-performance liquid chromatography |
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Authors: | Lv Chunguang Jia Guifang Zhu Wentao Qiu Jing Wang Xinquan Zhou Zhiqiang |
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Affiliation: | Department of Applied Chemistry, China Agricultural University, Beijing, China. |
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Abstract: | Cellulose tris(3,5-dimethylphenylcarbamate) (CDMPC) was synthesized and coated on aminopropylsilica to prepare a chiral stationary phase (CSP). HPLC methods were developed for the direct enantioseparation of 12 chiral triazole compounds on the CSP. The separations were made using normal phase methodology with a mobile phase consisting of n-hexane-alcohol (ethanol, 1-propanol, 1-butanol, 2-propanol, and t-butanol) in various portions. The column temperatures were studied for the optimization of the resolutions. The effects of structural features of the solutes on the discrimination between the enantiomers were examined. Baseline separation was easily obtained in many cases. |
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Keywords: | Chiral triazole Enantiomer separation HPLC Polysaccharide carbamate phase |
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