Substrate effects on interactions of lipid bilayer assemblies with bound nanoparticles |
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Authors: | Goertz Matthew P Goyal Nikita Bunker Bruce C Montaño Gabriel A |
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Affiliation: | Center for Integrated Nanotechnologies, Sandia National Laboratories, Albuquerque, NM, USA. mgoertz@sandia.gov |
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Abstract: | Understanding the interactions of nanoparticles with lipid membranes is crucial in establishing the mechanisms that govern assembly of membrane-based nanocomposites, nanotoxicology, and biomimetic inspired self-assembly. In this study, we explore binding of charged nanoparticles to lipid bilayers, both as liposomes and substrate supported assemblies. We find that the presence of a solid-support, regardless of curvature, eliminates the ability of zwitterionic fluid phase lipids to bind charged nanoparticles. |
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