Purines,pyrimidines, and related fused systems. 19. Use of S N H methodology for the synthesis of a new heterocyclic system,pyrrolo[3",2":3,4]pyrimido[4,5-c]pyridazine |
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Authors: | Gorunenko V V Gulevskaya A V Pozharskii A F |
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Institution: | (1) Rostov State University, 7 ul. Zorge, 344090 Rostov-on-Don, Russian Federation |
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Abstract: | Sonogashira cross-coupling of 3-chloro-6,8-dimethylpyrimido4,5-c]pyridazine-5,7(6H,8H)-dione with terminal alkynes afforded the corresponding 3-(alkyn-1-yl) derivatives. Oxidative amination of the latter compounds with primary alkylamines was accompanied by heterocyclization to give 6,8-dimethylpyrrolo3",2":3,4]pyrimido4,5-c]pyridazine-7,9(6H,8H)-diones. |
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Keywords: | 3-chloro-6 8-dimethylpyrimido[4 5-c]pyridazine-5 7(6H 8H)-dione 1-alkynes cross-coupling Sonogashira reaction catalysis palladium complexes 3-(alkyn-1-yl)-6 8-dimethylpyrimido[4 5-c]pyridazine-5 7(6H 8H)-diones oxidative amination 6 8-dimethylpyrrolo[3" 2":3 4]pyrimido[4 5-c]pyridazine-7 9(6H 8H)-diones |
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