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Quantitative detection of C-deuterated drugs by CARS microscopy and Raman microspectroscopy
Authors:Bergner Gero  Albert Christian R  Schiller Markus  Bringmann Gerhard  Schirmeister Tanja  Dietzek Benjamin  Niebling Stephan  Schlücker Sebastian  Popp Jürgen
Affiliation:Institute of Photonic Technologies, Albert-Einstein-Stra?e 9, 07745 Jena, Germany.
Abstract:The introduction of carbon-deuterium (C-D) bonds into drug compounds by organic synthesis is a non-invasive labelling approach, which does not alter the chemical and physiological properties of the drug itself. C-deuterated drugs exhibit characteristic vibrational signatures in the C-D stretching region around 2100-2300 cm(-1), which avoids spectral interference with contributions from a complex biological environment. In this paper, the quantitative detection of C-deuterated drugs by Raman microspectroscopy and single-band CARS microscopy is examined. Concentration-dependent studies on drugs with aliphatic and aromatic C-D moieties were performed in a two-channel microfluidic chip, using the corresponding non-deuterated (C-H) isotopologues as an internal reference.
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