| Carbopyronine荧光染料中间体的有效合成方法 |
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| 引用本文： | 谷利军,杨秉勤,刘飞龙,白银娟.Carbopyronine荧光染料中间体的有效合成方法[J].中国化学,2009,27(6):1199-1201. |
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| 作者姓名： | 谷利军 杨秉勤 刘飞龙 白银娟 |
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| 作者单位： | (西北大学化学系合成与天然功能分子化学教育部重点实验室，陕西，西安，710069) |
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| 摘 要： | 在非质子路易斯酸的辅助下高收率的合成了Carbopyronine荧光染料中间体2,7-双二甲氨基-9,10-二氢-9,9-二甲基蒽环。反应关键步骤是路易斯酸辅助下的环化反应，考查了几种路易斯酸的效果。确立了环化反应的最佳条件为： 2.5mol的路易斯酸与1mol的叔醇2在0 ˚C反应6 h，再于室温下反应10 h。
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| 关 键 词： | Carbopyronine荧光染料 合成 路易斯酸 环化反应 |
| 收稿时间： | 2008-9-27 |
| 修稿时间： | 2008-12-21 |
Efficient Synthetic Route to Carbopyronine Fluorenscent Dye Intermediate |
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| Lijun GU,Bingqin YANG,Feilong LIU,Yinjuan BAI.Efficient Synthetic Route to Carbopyronine Fluorenscent Dye Intermediate[J].Chinese Journal of Chemistry,2009,27(6):1199-1201. |
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| Authors: | Lijun GU Bingqin YANG Feilong LIU Yinjuan BAI |
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| Institution: | 1. Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, Department of Chemistry, Northwest University, Xi'an, Shaanxi 710069, China;2. Tel.: 0086‐029‐88302217;3. Fax: 0086‐029‐88302217 |
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| Abstract: | An efficient synthesis of 2,7‐bis(dimethylamino)‐9,10‐dihydro‐9,9‐dimethylanthracene via a non‐protic Lewis acid assisted cyclization reaction in a high yield was described. The key step was a Lewis acid assisted cyclization reaction. Several non‐protic Lewis acids were investigated and the optimal condition of cyclization reaction was determined to be 2.5 equiv. of Lewis acid at 0°C for 6 h and at room temperature for 10 h. |
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| Keywords: | carbopyronine fluorescent dye synthesis Lewis acid cyclization reaction |
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