Association of Spherical Porous Nanocluster Keplerate-Type Polyoxometalate Mo72Fe30 with Biologically Active Substances |
| |
Authors: | Alexander Ostroushko Ilya Gagarin Margarita Tonkushina Kirill Grzhegorzhevskii Olga Russkikh |
| |
Affiliation: | 1.Institute of Natural Sciences and Mathematics, Ural Federal University named after the First President of Russia B.N.Yeltsin,Yekaterinburg,Russia |
| |
Abstract: | The peculiarities of formation of ionic associates of the spherical porous nanocluster polyoxometalate [Mo72Fe30O252(CH3COO)12{Mo2O7(H2O)}2{H2Mo2O8(H2O)}(H2O)91] ~ 150H2O with biologically active substances, in particular, thiamine chloride using the methods of UV/Vis spectroscopy, pH-metry, laser light scattering (the measurement of Zeta potential and particle size distribution), Raman spectroscopy, infrared spectroscopy and inductively coupled plasma atomic emission spectroscopy has been studied. The location of thiamine molecules on POM’s surface is given. The solubility product of associate was estimated. The formation of molecular associates of polyoxometalate with insulin, albumin has been shown. Using the meglumine acridonacetate the influence of complexing agents on the possibility of obtaining associates on the basis of [Mo72Fe30O252(CH3COO)12{Mo2O7(H2O)}2{H2Mo2O8(H2O)}(H2O)91] ~ 150H2O has been studied. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|