首页 | 本学科首页   官方微博 | 高级检索  
     


Bismuth Oxyiodide Nanoflakes Showed Toxicity Against the Malaria Vector Anopheles stephensi and In Vivo Antiplasmodial Activity
Authors:Kadarkarai Murugan  Jagannathan Madhavan  Christina Mary Samidoss  Chellasamy Panneerselvam  Al Thabiani Aziz  Arumugam Malathi  Aruliah Rajasekar  Amuthavalli Pandiyan  Suresh Kumar  Abdullah A. Alarfaj  Akon Higuchi  Giovanni Benelli
Affiliation:1.Department of Zoology,Bharathiar University,Coimbatore,India;2.Thiruvalluvar University,Vellore,India;3.Solar Energy Lab, Department of Chemistry,Thiruvalluvar University,Vellore,India;4.Department of Biology, Faculty of Science,University of Tabuk,Tabuk,Saudi Arabia;5.Department of Biotechnology,Thiruvalluvar University,Vellore,India;6.Department of Medical Microbiology and Parasitology,Universiti Putra Malaysia (UPM),Serdang,Malaysia;7.Department of Botany and Microbiology, College of Science,King Saud University,Riyadh,Saudi Arabia;8.Department of Chemical and Materials Engineering,National Central University,Taoyuan,Taiwan;9.Department of Agriculture, Food and Environment,University of Pisa,Pisa,Italy;10.The BioRobotics Institute, Scuola Superiore Sant’Anna,Pontedera,Italy
Abstract:Anopheles stephensi is a mosquito vector of malaria, which is still considered a relevant public health problem due to increasing outdoor transmission, growing resistance to insecticides used to target vectors, and antiplasmodial drugs as well. Thus, there is a vital need to explore novel sources of effective compounds. In this study, the hydrothermal method was used for the synthesis of bismuth oxyiodide (BiOI) nanoflakes. Furthermore, the toxicity of BiOI nanoflakes was evaluated for the first time on A. stephensi, as well as in vivo against the malaria parasite Plasmodium berghei. The synthesis of BiOI nanoflakes was confirmed by various characterization techniques, including X-ray diffraction, Fourier transform-infrared spectroscopy, field emission scanning electron microscopy and transmission electron microscopy (HR-TEM). LC50 of BiOI nanoflakes on A. stephensi were 2.263 ppm (larva I), 3.414 ppm (II), 4.956 ppm (III), 6.983 ppm (IV) and 8.605 ppm (pupae). In vivo antiplasmodial experiments conducted on P. berghei infecting albino mice showed 27.2% of chemosuppression after 4 days of treatment with 300 mg/kg/day of BiOI, a lower performance if compared to chloroquine. Overall, our results suggested that hydrothermal synthesis of BiOI nanoflakes may be considered to develop newer and safer tools for malaria vector control.
Keywords:
本文献已被 SpringerLink 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号