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An efficient and mild protocol for the synthesis of unsymmetrical ureas in the absence of catalyst and additives
Authors:Rahman Hosseinzadeh  Yaghoub Sarrafi  Nora Aghili
Affiliation:Department of Organic Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran
Abstract:A new practical method for the synthesis of unsymmetrical ureas was achieved by reaction of phenylurea with primary and secondary amines under neutral and mild condition in very good yields. The reaction took place in refluxing dioxane and does not require any catalyst or additives.
Keywords:Unsymmetrical ureas  Phenyl urea  Amines  Uncatalyzed reaction
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