Asymmetric synthesis of cis-5-tert-butylproline with metal carbenoid NH insertion |
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| Authors: | Davis Franklin A Yang Bin Deng Jianghe |
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| Affiliation: | Department of Chemistry, Temple University, Philadelphia, Pennsylvania 19122, USA. fdavis@temple.edu |
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| Abstract: | The highly stereoselective intramolecular metal carbenoid insertion reaction of sulfinimine-derived delta-amino alpha-diazoesters is used to prepare cis-5-tert-butylproline. A concerted or nearly concerted metal carbenoid N-H insertion reaction mechanism is proposed. |
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