The preparation of fluorescence-quenched probes for use in the characterization of human factor Xa substrate binding domains |
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| Authors: | Bromfield Karen M Cianci Julia Duggan Peter J |
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| Institution: | Centre for Green Chemistry, Monash University, Clayton, Victoria, 3800, Australia. |
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| Abstract: | The preparation and characterization by LCMS of a library of 55 fluorescence- quenched peptides is described. The peptides bear a terminal anthranilamide fluorophore and a penultimate 2,4-dinitrophenyl-L-lysine quencher, and will be used to probe the substrate binding domain of the human blood coagulation enzyme, factor Xa. |
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