Morphology and permeability of cellulose/chitin blend membranes |
| |
Authors: | Songmiao Liang Lina Zhang Jian Xu |
| |
Affiliation: | 1. Department of Chemistry, Wuhan University, Wuhan 430072, PR China;2. State Key Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, PR China |
| |
Abstract: | A series of biodegradable cellulose/chitin blend membranes were successfully prepared from blend solution of cellulose and chitin in 9.5 wt% NaOH/4.5 wt% thiourea aqueous solution coagulating with 5.0 wt% (NH4)2SO4. The influence of chitin content on the morphology and structure of the membranes was studied by scanning electron microscopy, environmental scanning electron microscopy and wide-angle X-ray diffractometry, as well as Fourier transform infrared spectroscopy. Using double-cell method and solution depletion method, the permeability and partition coefficients of three model drugs (ceftazidine, cefazolin sodium, and thiourea) were determined in phosphate buffer solution to clarify the diffusion mechanism governing transport of solutes in these membranes. Diffusion coefficients were calculated from the permeability and partition coefficients in terms of Fick's law. The effects of the chitin content, pH, ionic strength, molecular size and temperature on the drug diffusion were also studied. Our results revealed that all of the membranes had a porous-like structure. The introduction of chitin exhibited great influence on the morphology and crystal structure of the blend membranes, resulting in a significant different permeability. For the first time, a dual diffusion mechanism with some hindrance of molecular diffusion via polymer obstruction was employed to explain the transport of drugs in the membranes. |
| |
Keywords: | Permeability Partition Cellulose Chitin Membrane |
本文献已被 ScienceDirect 等数据库收录! |
|