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High resolution high field rodent cardiac imaging with flow enhancement suppression |
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| Authors: | Stephen E. Rose Stephen J. Wilson Fernando O. Zelaya Stuart Crozier David M. Doddrell |
| Affiliation: | Centre for Magnetic Resonance, University of Queensland, St. Lucia Qld 4072, Australia |
| Abstract: | A method that incorporates cardiorespiratory-gated 2DFT spin-echo imaging with blood flow enhancement suppression is described which enables high resolution microimaging of the rodent heart. This methodology was applied to obtain in vivo cardiac mouse and rat images with in-plane resolutions of 100–200 μm using high field vertical bore magnet systems. Suppression of intraventricular blood flow enhancement was achieved using a combined spin-echo/gradient-refocussed sequence to dephase magnetization from flowing spins prior to imaging. |
| Keywords: | Rodent cardiac MR imaging Cardiorespiratory triggered imaging Blood flow enhancement compensation |
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