Reaction of cyclic thioureas with chloroacylpiperazines |
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Authors: | S Groszkowski I Krezhel L Kozycka |
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Institution: | (1) Pharmaceutical Department, Medical Academy of Sciences, Lodz |
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Abstract: | S-Alkylation products are formed in the reaction of tetrahydropyrimidine-2-thione and hexahydro-1,3-diazepine-2-thione with chloroacylpiperazines in dimethylformamide at room temperature; dihydrothiazolo3,2-a]pyrimidine and tetrahydrothiazolo3,2-a]-1,3]diazepine systems are obtained in refluxing ethanol. It is shown that the S-alkyl derivatives are very readily converted to condensed systems.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 823–826, June, 1984. |
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