Synthesis and transformations of 1-(4-hydroxyphenyl)dihydrouracils

N-(4-Hydroxyphenyl)--alanine and its methyl derivatives, as well as p-hydroxyphenylamino-, '-dipropionic acid, were obtained by the reaction of p-aminophenol with methyl acrylate and acrylic, methacrylic, and crotonic acids. The -alanines were converted to the corresponding hydrazides and 1-(4-hydroxyphenyl)dihydro- and thiodihydrouracils, which were decyclized by the action of alkalis to ureido and thioureido acids and were dehydrogenated by heating with sulfur to give uracils. The dihydro- and thiodihydrouracils were alkylated and acetylated.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1400–1406, October, 1982.