| New Metabolites of Aconitine in Rabbit Urine |
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| 作者姓名： | HongGuiZHANG XiangGuoSHI |
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| 作者单位： | [1]DepartmentofNaturalPharmaceuticalChemistry,SchoolofPharmacy,JilinUniversity,Changchun130021 [2]LaboratoryofDrugMetabolismandPharmacokinetics,ShenyangPharmaceuticalUniversity,Shenyang1100 |
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| 摘 要： | A sensitive analytical method to identify and determine aconitine and its metabolites in rabbit urine was developed by liquid chromatography-electrospray ionization mass spectrometry (LC/ESI-MS^n). In this method,aconitine and its four metabolites in rabbit urine were isolated and deduced as 16-O-demethylaconine (M1), benzoylaconine (M2),16-O-demethylbenzoylaconine (M3) and aconine(M4).M1 and M3 are new metabolites of aconitine and M2 and M4 are first identified in rabbit urine.
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| 关 键 词： | 野兔尿 代谢物 乌头碱 |
New Metabolites of Aconitine in Rabbit Urine |
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| Hong Gui ZHANG,Xiang Guo SHI,Ying Sun,Ming Yu DUAN,Da Fang ZHONG.New Metabolites of Aconitine in Rabbit Urine[J].Chinese Chemical Letters,2002,13(8):758-760. |
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| Authors: | Hong Gui ZHANG Xiang Guo SHI Ying Sun Ming Yu DUAN Da Fang ZHONG |
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| Abstract: | A sensitive analytical method to identify and determine aconitine and its metabolites in rabbit urine was developed by liquid chromatography-electrospray ionization mass spectrometry (LC/ESI-MSn).In this method,aconitine and its four metabolites in rabbit urine were isolated and deduced As 16-O-demethylaconine(M1), benzoylaconine(M2), 16-O-demethylbenzoylaconine (M3)and aconine(M4).M1 and M3 are new metabolites of aconitine and M2 and M4 are first identified in rabbit urine. |
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| Keywords: | Aconitum metabolites aconitine LC/MS |
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