Domino process optimized via ab initio study for an alternative access to bicyclic lactams |
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| Authors: | Comesse Sébastien Martel Arnaud Daïch Adam |
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| Affiliation: | URCOM, EA 3221, CNRS FR3038-INC3M, UFR S.T. de l' Universite? du Havre, BP 540, 25 rue Philippe Lebon, F-76058 Le Havre cedex, France. sebastien.comesse@univ-lehavre.fr |
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| Abstract: | A totally new acid-free domino process to access highly functionalized bicyclic γ- and δ-lactams starting from commercially available and inexpensive ethoxymethylene derivatives is reported. Mechanisms elucidated by computational calculations led to new reaction conditions that boosted the yields up to 3.5 times higher. |
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