Synthesis and acid-base transformations of 8-substituted 10-phenyl-10-hydroxy-10H- pyrido [2,3-b ]chromenes |
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Authors: | V M Petrichenko M E Konshin |
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Institution: | (1) Perm Pharmaceutical Institute, 614600 Perm |
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Abstract: | The corresponding 2-(p-substituted phenoxy)-3-aroylpyridines were obtained by the reaction of 2-(p-substituted phenoxy)nicotinonitriles with phenylmagnesium bromide. It is shown that they are readily cyclized to 8-substituted 10-phenyl-10-hydroxy-10H-pyrido2,3-b]chromenes by the action of concentrated sulfuric acid in glacial acetic acid. The pKR+ values of the cyclization products, which range from–7.70 to –10.83 and correlate with the p
0 substituent constants, were determined by spectrophotometry.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 614–616, May, 1982. |
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