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An enantioselective organocatalyzed aza-MBH domino process: application to the facile synthesis of tetrahydropyridines |
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| Authors: | Shinobu TakizawaNaohito Inoue Hiroaki Sasai |
| Institution: | The Institute of Scientific and Industrial Research (ISIR), Osaka University Mihogaoka, Ibaraki-shi, Osaka 567-0047, Japan |
| Abstract: | A chiral acid-base organocatalyst was found to promote an aza-MBH domino process between α,β-unsaturated carbonyl compounds and N-tosylimines to afford tetrahydropyridine derivatives with high enantioselectivity. |
| Keywords: | Acid-base organocatalyst Domino reaction Aza-MBH reaction Tetrahydropyridines Enantioselective reaction |
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