Synthesis,characterization and DNA binding studies of ruthenium(II) complexes: [Ru(bpy)2(dtmi)]2+ and [Ru(bpy)2(dtni)]2+ |
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Authors: | Yun-Jun Liu Xin Yu Wei Wen-Jie Mei Li-Xin He |
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Affiliation: | (1) School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510006, P. R. China |
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Abstract: | Two new ruthenium(II) polypyridyl complexes (1) (dtmi = 3-(pyrazin-2-yl)-as-triazino[5,6-f]-5-methoxylisatin) and (2) (dtni = 3-(pyrazin-2-yl)-as-triazino[5,6-f]-5-nitroisatin) have been synthesized and characterized by elemental analysis, FAB-MS, ES-MS and 1H-n.m.r. The DNA-binding patterns of complexes were investigated by spectroscopic titration, viscosity measurements and thermal denaturation. The results indicate that the complexes (1) and (2) interact with calf thymus DNA (CT-DNA) by intercalative mode. Due to the withdrawing electronic substitutent in the intercalative ligand, ptni, the DNA-binding affinity of the complexes (2) is larger than that complex (1) does. |
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