Cytosine-gated hole creation and transfer in DNA in aqueous solution |
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| Authors: | Anderson Robert F Shinde Sujata S Maroz Andrej |
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| Institution: | Department of Chemistry, The University of Auckland, Auckland 1, New Zealand. r.anderson@auckland.ac.nz |
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| Abstract: | The selenite radical, SeO3-, has been found to selectively produce the cytosyl radical upon one-electron oxidation of duplex DNA. This is at first a surprising result as SeO3- can only oxidize guanine of the DNA bases, implying that the transiently formed guanyl radical cation must transpose into the neutral cytosyl radical with loss of a proton. Back oxidation to produce the neutral guanyl radical, in competition with another fixation reaction, is observed. |
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