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Biodegradable Oxamide‐Phenylene‐Based Mesoporous Organosilica Nanoparticles with Unprecedented Drug Payloads for Delivery in Cells |
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| Authors: | Dr Jonas G Croissant Yevhen Fatieiev Dr Khachatur Julfakyan Jie Lu Dr Abdul‐Hamid Emwas Dr Dalaver H Anjum Haneen Omar Prof Fuyuhiko Tamanoi Prof Jeffrey I Zink Prof Niveen M Khashab |
| Institution: | 1. Smart Hybrid Materials Laboratory, Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia;2. Department of Chemistry and Biochemistry, California NanoSystems Institute, Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, California, USA;3. Department of Microbiology, Immunology and Molecular Genetics, California NanoSystems Institute, Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, California, USA;4. Imaging and Characterization Laboratory, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia |
| Abstract: | We describe biodegradable mesoporous hybrid nanoparticles (NPs) in the presence of proteins and their applications for drug delivery. We synthesized oxamide phenylene‐based mesoporous organosilica nanoparticles (MON) in the absence of a silica source which had remarkably high organic content and high surface areas. Oxamide functions provided biodegradability in the presence of trypsin model proteins. MON displayed exceptionally high payloads of hydrophilic and hydrophobic drugs (up to 84 wt %), and a unique zero premature leakage without the pore capping, unlike mesoporous silica. MON were biocompatible and internalized into cancer cells for drug delivery. |
| Keywords: | biodegradable bridged silsesquioxanes drug delivery enzymes nanoparticles |