Carboxylation of Phenols with CO2 at Atmospheric Pressure |
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| Authors: | Junfei Luo Sara Preciado Pan Xie Prof Igor Larrosa |
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| Institution: | 1. School of Chemistry, University of Manchester, Manchester, UK;2. School of Biological and Chemical Sciences, Queen Mary University of London, Joseph Priestley Building, London, UK |
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| Abstract: | A convenient and efficient method for the ortho‐carboxylation of phenols under atmospheric CO2 pressure has been developed. This method provides an alternative to the previously reported Kolbe–Schmitt method, which requires very high pressures of CO2. The addition of a trisubstituted phenol has proved essential for the successful carboxylation of phenols with CO2 at standard atmospheric pressure, allowing the efficient preparation of a broad variety of salicylic acids. |
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| Keywords: | carbon dioxide Kolbe– Schmitt reaction phenols salicylic acids synthetic methods |
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