Acceptorless Dehydrogenative Oxidation of Secondary Alcohols Catalysed by Cp*IrIII–NHC Complexes
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Authors: | Prof Süleyman Gülcemal Prof Derya Gülcemal Dr George F S Whitehead Prof Jianliang Xiao |
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Institution: | 1. Department of Chemistry, University of Liverpool, Liverpool, UK;2. Department of Chemistry, Ege University, Bornova-Izmir, Turkey |
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Abstract: | A series of new IrIII complexes with carbene ligands that contain a range of benzyl wingtip groups have been prepared and fully characterised by NMR spectroscopy, HRMS, elemental analysis and X‐ray diffraction. All the complexes were active in the acceptorless dehydrogenation of alcohol substrates in 2,2,2‐trifluoroethanol to give the corresponding carbonyl compounds. The most active complex bore an electron‐rich carbene ligand; this complex was used to catalyse the highly efficient and chemoselective dehydrogenation of a wide range of secondary alcohols to their respective ketones, with turnover numbers up to 1660. Mechanistic studies suggested that the turnover of the dehydrogenation reaction is limited by the H2‐formation step. |
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Keywords: | acceptorless dehydrogenation alcohols carbenes iridium oxidation |
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