A Concise Synthesis of a BODIPY-Labeled Tetrasaccharide Related to the Antitumor PI-88 |
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| Authors: | Juan Ventura,Clara Uriel,Ana M. Gomez,Edurne Avellanal-Zaballa,Jorge Bañ uelos,Inmaculada Garcí a-Moreno,Jose Cristobal Lopez |
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| Affiliation: | 1.Instituto de Química Orgánica General, IQOG-CSIC, Juan de la Cierva 3, 28006 Madrid, Spain; (J.V.); (C.U.);2.Departamento de Química Física, Universidad del Pais Vasco-EHU, Apartado 644, 48080 Bilbao, Spain;3.Instituto de Química-Física “Rocasolano”, IQFR-CSIC, Serrano 119, 28006 Madrid, Spain; |
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| Abstract: | A convergent synthetic route to a tetrasaccharide related to PI-88, which allows the incorporation of a fluorescent BODIPY-label at the reducing-end, has been developed. The strategy, which features the use of 1,2-methyl orthoesters (MeOEs) as glycosyl donors, illustrates the usefulness of suitably-designed BODIPY dyes as glycosyl labels in synthetic strategies towards fluorescently-tagged oligosaccharides. |
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| Keywords: | PI-88 glycosylation 1 2-methyl orthoesters BODIPY fluorescent labeling |
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