Asymmetric nitroaldol reaction catalyzed by a C2-symmetric bisoxazolidine ligand |
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Authors: | Liu Shuanglong Wolf Christian |
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Affiliation: | Department of Chemistry, Georgetown University, Washington, DC 20057, USA. |
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Abstract: | A C2-symmetric bisoxazolidine was found to effectively catalyze the asymmetric Henry reaction of aliphatic and aromatic aldehydes. Beta-hydroxy nitroalkanes were produced in up to 99% yield and 95% ee. The bisoxazolidine-catalyzed nitroaldol formation requires relatively short reaction times, proceeds under mild conditions and is applicable to a wide range of substrates including sterically hindered aldehydes. |
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