Efficient synthesis of highly substituted Pyrrolin-4-ones via PIFA-mediated cyclization reactions of enaminones |
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| Authors: | Huang Jie Liang Yongjiu Pan Wei Yang Yang Dong Dewen |
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| Affiliation: | Department of Chemistry, Northeast Normal University, Changchun 130024, China. |
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| Abstract: | A convenient and efficient synthesis of highly substituted pyrrolin-4-ones is developed via the PIFA-mediated cyclization reactions of readily available enaminones, and a mechanism involving sequential cleavage of N-C bond, formation of new N-C bond, intramolecular addition reaction, and benzilic acid type rearrangement is proposed. |
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