Copper-catalyzed synthesis of enantioenriched tetraarylethanes |
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| Authors: | Jen Wendy S Truppo Matthew D Amos Deborah Devine Paul McNevin Michael Biba Mirlinda Campos Kevin R |
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| Affiliation: | Department of Process Research, Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, USA. wendy_jen@merck.com |
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| Abstract: | Herein we report the asymmetric synthesis of 1,2-dipyridyl-1,2-diarylethanes via an unusual Cu(I)-catalyzed dimerization reaction. Subjection of a variety of enantioenriched substituted 2-pyridyl alcohols to a one-pot protocol generates the desired products in good yields and diastereoselectivities and with ee's up to >99%. |
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