Enantioselective conjugate radical addition to alpha'-hydroxy enones |
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| Authors: | Lee Sunggi Lim Chae Jo Kim Sunggak Subramaniam Rajesh Zimmerman Jake Sibi Mukund P |
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| Affiliation: | Center for Molecular Design & Synthesis and Department of Chemistry, School of Molecular Science (BK-21), Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea. |
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| Abstract: | Enantioselective conjugate radical addition to alpha'-hydroxy alpha,beta-unsaturated ketones, compounds containing bidentate donors, has been investigated. It has been found that radical additions to alpha'-hydroxy alpha,beta-unsaturated ketones in the presence of Mg(NTf2)2 and bisoxazoline ligand 5a proceeded cleanly, yielding the addition products in high chemical yields and good enantiomeric excesses. |
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