| Synthesis of 2,5-disubstitued benzimidazole using SnCl2-catalyzed reduction system at room temperature简 |
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| 基金项目： | This project is supported by Shanghai Municipal Natural Science Foundation (No. 12ZR1434900), International Collaboration on Drugs and Diagnostics Innovation of Tropical Diseases in China (International S&T Cooperation 2010DFB73280). |
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| 摘 要： | Stannous chloride dihydrate is used as an efficient catalyst in reductive cyclization of 2-nitro-5- substituted aniline Schiff base leading to stable 2,5-disubstitued benzimidazole derivatives in excellent yields with good purity. It provides a novel method of synthesis of 2,5-disubstitued benzimidazole under reductive system at room temperature.
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| 关 键 词： | 苯并咪唑衍生物 高效催化剂 还原系统 二取代 室温 合成 取代苯并咪唑 二水合物 |
| 收稿时间： | 2013-09-02 |
| 修稿时间： | 2013-09-13 |
Synthesis of 2,5-disubstitued benzimidazole using SnCl2-catalyzed reduction system at room temperature |
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| Li-Ping Duan,Qiang Li,Ning-Bo Wu,Dong-Fang Xu,Hao-Bing Zhang. Synthesis of 2,5-disubstitued benzimidazole using SnCl2-catalyzed reduction system at room temperature[J]. Chinese Chemical Letters, 2014, 25(1): 155-158. DOI: 10.1016/j.cclet.2013.10.014 |
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| Authors: | Li-Ping Duan Qiang Li Ning-Bo Wu Dong-Fang Xu Hao-Bing Zhang |
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| Affiliation: | a National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, WHO Collaborating Centre for Malaria, Schistosomiasis, and Filariasis, Key laboratory of Parasitology and Vector Biology at National Institute of Parasitic Diseases, Shanghai 200025, China;b Shanghai Normal University, Shanghai 200005, China |
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| Abstract: | Stannous chloride dihydrate is used as an efficient catalyst in reductive cyclization of 2-nitro-5-substituted aniline Schiff base leading to stable 2,5-disubstitued benzimidazole derivatives in excellent yields with good purity. It provides a novelmethod of synthesis of 2,5-disubstitued benzimidazole under reductive system at room temperature. |
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| Keywords: | Stannous chloride dihydrate Reductive cyclization Benzimidazole derivatives |
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