| Silica gel catalyzed α-bromination of ketones using N-bromosuccinimide: An easy and rapid method |
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| 作者姓名： | Bodireddy Mohan Reddy Velpula Venkata Ramana Kumar Nallagondu Chinna Gangi Reddy Siripragada Mahender Rao |
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| 作者单位： | [1]Department of Chemistry, School of Physical Sciences, Yogi Vemana University, Ifadapa 516 003, [2]India Research ＆ Development （AH） Centre, Panacea Biotech Ltd., B-1 Extn./A-27, Mohan Co-operative Industrial Estate, New Delhi 110044, India |
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| 基金项目： | We express our thanks to Council of Scientific and Industrial Research (CSIR), New Delhi, Government of India for the financial support under major research project (No. 01 (2391)/10/EMR-II). |
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| 摘 要： | An easy and rapid method for the a-bromination of ketones using N-bromosuccinimide(NBS) catalyzed by silica gel in methanol under reflux conditions was developed. The expected products were formed in excellent isolated yields within a short period of time(5–20 min). Major advantages of the present procedure include use of inexpensive and readily available catalyst, exclusion of pre- and post-chemical treatment of catalyst and use of methanol as solvent instead of ethers and chlorinated solvents.
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| 关 键 词： | Heterogeneous catalysis α-Bromination N-bromosuccinimide(NBS) Silica gel Ketones |
| 收稿时间： | 2013-04-28 |
| 修稿时间： | 2013-08-30 |
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